Tyrphostin AG 528

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Tyrphostin AG 528 是 EGFR (IC50: 4.9 μM) 和 ErbB2 (IC50: 2.1 μM) 的抑制剂。

Tyrphostin AG-528, also known as Tyrphostin B66, is a EGFR protein tyrosine kinase inhibitor.

In the present study, the interaction between drug Tyrphostin AG528 and CNT(6,6-6) nanotube by Density Functional Theory (DFT) calculations in solvent water has been investigated for the first time. According to the calculations, intermolecular hydrogen bonds take place between an active position of the molecule Tyrphostin AG528 and hydrogen atoms of the nanotube which play an important role in the stability of complex CNT(6,6- 6)/Tyrphostin AG528. The non-bonded interaction effects of the molecule Tyrphostin AG528 with CNT(6,6-6) nanotube on the electronic properties, chemical shift tensors and natural charge have also been detected. The natural bond orbital (NBO) analysis suggested that the molecule Tyrphostin AG528 as an electron donor and the CNT(6,6-6) nanotube play the role of an electron acceptor at the complex CNT(6,6-6)/Tyrphostin AG528.

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Tyrphostin AG-528 | Tyrphostin-B66

GPCR/G Protein

Antibacterial

EGFR|ErbB2

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133550-49-9

306.32

C18H14N2O3

>98% (HPLC)

DMSO : 25 mg/mL 81.61 mM;

C1CN(C2=CC=CC=C21)C(=O)/C(=C/C3=CC(=C(C=C3)O)O)/C#N

N-(3′,4′-Dihydroxybenzylidenecyanoacetyl)indoline

(-20℃)

With Ice Pack

≥ 2 years